Lecture 8: Functional and Qualitative Disorders of Platelets

Michele P. Lambert MD

Presentation Date:

October 26, 2023

Platelets have a critical role in primary hemostasis.

A wide range of hereditary and acquired disorders impact platelet function, leading to bleeding

Objectives:
1. Recognize the common clinical presentation of qualitative platelet disorders
2. Understand the typical mechanisms by which inherited defects of platelet function occur and list a disorder that exemplifies each mechanism
3. Describe the most common acquired platelet function defects and their clinical presentations.

Michele P. Lambert MD
Medical Director of the Special Coagulation Laboratory
Attending Physician in the Division of Hematology
Children's Hospital of Philadelphia

Genomic landscape of megakaryopoiesis and platelet function defects.

Schematic cartoon representing the proteins mutated in inherited platelet function disorders.

Elisa Bianchi et al. Blood 2016;127:1249-1259

Slide Deck